Stiris T A, Suguihara C, Flynn J, Quero J, Bancalari E
Department of Pediatrics, La Paz Children's Hospital, Spain.
Biol Neonate. 1996;69(2):101-8. doi: 10.1159/000244284.
The effect of the cyclooxygenase inhibitor ibuprofen (IB) on choroidal (ChBF) and retinal (RBF) blood flow during hyperoxia was examined in 21 spontaneously breathing newborn piglets.
ChBF and RBF were measured using radiolabelled microspheres before and 30 min after either saline or IB (30 mg/kg, i.v.) infusion in room air and subsequently, after 90 min of hyperoxia (O2).
The basal RBF and ChBF did not change after IB infusion. However, during hyperoxia a significant decrease in RBF was observed in the IB group (54 +/- 5 to 37 +/- 3 ml/min/100 g, p < 0.02) and in the control group (54 +/- 3 to 37 +/- 5 ml/min/100 g, p < 0.02). Also, ChBF decreased in the IB group (2,635 +/- 446 to 1,670 +/- 199 ml/min/100 g, p < 0.02) and in the control group, (2,997 +/- 346 to 2,014 +/- 246 ml/min/100 g,p < 0.02) during hyperoxia.
Despite cyclooxygenase inhibition with IB, RBF and ChBF decreased to the same extent as in the control group following exposure to O2. These data suggest that hyperoxia decrease RBF and ChBF through mechanisms and/or mediators other than the cyclooxygenase by-products of arachidonic acid metabolism.
在21只自主呼吸的新生仔猪中，研究环氧合酶抑制剂布洛芬（IB）对高氧期间脉络膜血流（ChBF）和视网膜血流（RBF）的影响。
在常氧条件下，于静脉输注生理盐水或IB（30mg/kg）前及输注后30分钟，使用放射性微球测量ChBF和RBF，随后在高氧（O2）90分钟后再次测量。
输注IB后，基础RBF和ChBF未发生变化。然而，在高氧期间，IB组的RBF显著降低（54±5至37±3ml/min/100g，p<0.02），对照组的RBF也显著降低（54±3至37±5ml/min/100g，p<0.02）。此外，在高氧期间，IB组的ChBF降低（2635±446至1670±199ml/min/100g，p<0.02），对照组的ChBF也降低（2997±346至2014±246ml/min/100g，p<0.02）。
尽管使用IB抑制了环氧合酶，但暴露于O2后，RBF和ChBF的降低程度与对照组相同。这些数据表明，高氧通过花生四烯酸代谢的环氧合酶副产物以外的机制和/或介质降低RBF和ChBF。
