脾切除小鼠对甲基胆蒽诱导肿瘤的抵抗力增强。
Increased resistance in splenectomized mice to a methylcholanthrene-induced tumour.
作者信息
Chang R W, Turk J L
出版信息
Br J Cancer. 1977 Jun;35(6):768-76. doi: 10.1038/bjc.1977.118.
Abstract
Prior splenectomy increased the resistance of BALB/c mice to a syngeneic methylcholanthrene-induced ascitic tumour inoculated i.p. The survival rate of splenectomized mice was 81-6% while those of normal and sham-operated controls were 11-5% and 20% respectively. The effect of splenectomy, however, was seen only within the dose range of 10(3) to 10(4) tumour cells. This effect of splenectomy was abolished by the transfer to mice of serum from tumour-bearing mice, and of spleen cells from normal donors, immediately after the inoculation of tumour cells. Cell-free ascitis fluid did not abolish the effect of splenectomy. The findings suggest that there is a subpopulation of spleen cells which produces a tumour growth enhancing factor which is found in the serum of tumour-bearing mice.
摘要
先前的脾切除术增强了BALB/c小鼠对腹腔接种的同基因甲基胆蒽诱导的腹水瘤的抵抗力。脾切除小鼠的存活率为81.6%，而正常对照组和假手术对照组的存活率分别为11.5%和20%。然而，脾切除的效果仅在10³至10⁴个肿瘤细胞的剂量范围内可见。接种肿瘤细胞后立即将荷瘤小鼠的血清和正常供体的脾细胞转移到小鼠体内，可消除脾切除的这种效果。无细胞腹水液不能消除脾切除的效果。这些发现表明，存在一群脾细胞，它们产生一种在荷瘤小鼠血清中发现的肿瘤生长增强因子。
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