Yamagishi H, Oka T, Hashimoto I, Pellis N R, Kahan B D
Jpn J Surg. 1984 Jan;14(1):72-7. doi: 10.1007/BF02469606.
The effect of splenectomy on neoplastic outgrowth was examined prior to and after implantation of methylcholanthrene-induced C3H/He murine tumors. Splenectomy performed 12 days before tumor inoculation did not affect the tumor outgrowth, however, both splenectomy and sham operation performed shortly before tumor inoculation resulted in significant tumor facilitation compared with the non-operated group, suggesting that this accelerated tumor was not related to the presence or absence of splenic tissue, but rather to systemically-induced immunosuppression. While splenectomy performed 6, 9, 12 days after tumor inoculation did not alter the tumor growth, splenectomy performed early (3 days) or late stage (20 days) after tumor cell challenge revealed a retarded neoplastic outgrowth, compared with the sham operated group. These results suggest that splenectomy in very early and late stages of tumor-bearing host may be effective for tumor treatment.
在植入甲基胆蒽诱导的C3H/He小鼠肿瘤之前和之后，研究了脾切除术对肿瘤生长的影响。在肿瘤接种前12天进行脾切除术不影响肿瘤生长，然而，与未手术组相比，在肿瘤接种前不久进行脾切除术和假手术均导致肿瘤明显加速生长，这表明这种加速生长的肿瘤与脾组织的有无无关，而是与全身诱导的免疫抑制有关。虽然在肿瘤接种后6、9、12天进行脾切除术不改变肿瘤生长，但与假手术组相比，在肿瘤细胞攻击后早期（3天）或晚期（20天）进行脾切除术显示肿瘤生长受到抑制。这些结果表明，在荷瘤宿主的极早期和晚期进行脾切除术可能对肿瘤治疗有效。
