Sheldon P W, Hill S A
Br J Cancer. 1977 Jun;35(6):795-808. doi: 10.1038/bjc.1977.121.
Tumour experiments including local control after X-irradiation have been performed, using a new technique that eliminates the need for anaesthetics in restraining the animals. This system has been used to investigate the degree of sensitization that can be achieved with ICRF 159 and 4 strongly electron-affinic radiosensitizers, nifurpipone dihydrochloride, metronidazole, Ro-11-3696 and Ro-07-0582. No significant enhancement of the radiation effect was observed with ICRF 159. Significant sensitization was achieved by all 4 nitro-heterocyclic compoinds, Ro-07-0582 being the most effective, metronidazole and Ro-11-3696 the next, and nifurpipone dihydrochloride the least effective. For Ro-07-0582 and metronidazole, several concentrations were investigated, and the interval between injection with Ro-07-0582 and irradiation was varied: an interval of 30 min gave more sensitization than an interval of 90 min. The results from the local control experiments using Ro-07-0582 have been compared with those obtained from regrowth delay experiments. The radiosensitization obtained by the Ro-07-0582 increased with the X-ray dose above 25 gray. Both metronidazole and Ro-07-0582 gave significant enhancement effect at serum concentrations which can be achieved in man.
已经开展了包括X射线照射后局部控制的肿瘤实验，采用了一种新技术，该技术无需使用麻醉剂来束缚动物。该系统已用于研究用ICRF 159和4种强电子亲和性放射增敏剂（盐酸硝呋哌酮、甲硝唑、Ro-11-3696和Ro-07-0582）能够实现的增敏程度。未观察到ICRF 159对辐射效应有显著增强作用。所有4种硝基杂环化合物均实现了显著增敏，Ro-07-0582最有效，甲硝唑和Ro-11-3696次之，盐酸硝呋哌酮最无效。对于Ro-07-0582和甲硝唑，研究了几种浓度，并改变了注射Ro-07-0582与照射之间的间隔时间：30分钟的间隔比90分钟的间隔增敏效果更好。已将使用Ro-07-0582进行局部控制实验的结果与从再生长延迟实验获得的结果进行了比较。Ro-07-0582产生的放射增敏作用随X射线剂量高于25格雷而增加。甲硝唑和Ro-07-0582在人体能够达到的血清浓度下均产生了显著的增强效果。
