RO-07-0582对实验小鼠肿瘤中缺氧细胞的放射增敏和杀细胞作用以及X线损伤的修复
Radiosensitizing and cytocidal effects on hypoxic cells of RO-07-0582, and repair of x-ray injury, in an experimental mouse tumour.
作者信息
Hill S A, Fowler J F
出版信息
Br J Cancer. 1977 Apr;35(4):461-9. doi: 10.1038/bjc.1977.69.
Abstract
The delay in regrowth to 10 mm diameter of a transplanted carcinoma in mice was used to estimate the effect of the hypoxic-cell radiosensitizer Ro-07-0582. When 1 mg/g body wt. was given before a single dose of X-rays, a dose-enhancement ratio of 2-0 was found. When the drug was given immediately after irradiation, a large cytotoxic effect was observed, equivalent to an enhancement ratio of 1-3. These results were confirmed by determining the X-ray doses required for the local control of 50% of the tumours at 80 days after irradiation. The capacity of the tumour for repair of sublethal X-ray injury within 24 h was similar to that for several normal tissues.
摘要
利用小鼠移植癌再生长至直径10毫米的延迟来评估乏氧细胞放射增敏剂Ro-07-0582的效果。当在单次X射线照射前给予1毫克/克体重时，发现剂量增强比为2.0。当在照射后立即给予该药物时，观察到较大的细胞毒性作用，相当于增强比为1.3。通过确定照射后80天局部控制50%肿瘤所需的X射线剂量，证实了这些结果。肿瘤在24小时内修复亚致死性X射线损伤的能力与几种正常组织相似。
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