Palit G
Department of Pharmacology, KG's Medical College, Lucknow, India.
Indian J Exp Biol. 1995 Dec;33(12):980-2.
Graded dose of amphetamine (AMP; 1-4 mg/kg, im) induced suppression of approach, contact, body jerk, grooming and food forage, hypervigilance (checking), stereotyped behaviour and oral hyperkinesia in rhesus monkeys. Pretreatment with haloperidol--a dopamine receptor blocking agent (0.04 mg/kg, im)--significantly suppressed the AMP induced hypervigilance, stereotypy and oral hyperkinesia but was unable to reverse other AMP induced behavioural effects in the monkeys. Haloperidol (0.01-0.04 mg/kg, im) per se produced decrease in social and solitary behaviour and marked cataleptic posture. The results suggest that dopamine may be playing an important role in the mediation of many AMP induced behavioural changes in primates.
不同剂量的苯丙胺（AMP；1 - 4毫克/千克，肌肉注射）可抑制恒河猴的接近、接触、身体抽搐、梳理毛发和觅食行为，导致过度警觉（检查）、刻板行为和口腔多动症。用氟哌啶醇（一种多巴胺受体阻断剂，0.04毫克/千克，肌肉注射）进行预处理，可显著抑制AMP诱导的过度警觉、刻板行为和口腔多动症，但无法逆转AMP在猴子身上诱导的其他行为效应。氟哌啶醇（0.01 - 0.04毫克/千克，肌肉注射）本身会导致社交和独处行为减少以及明显的僵住姿势。结果表明，多巴胺可能在介导灵长类动物中许多由AMP诱导的行为变化中起重要作用。
