Zucali J R, Mirand E A
Br J Haematol. 1977 Apr;35(4):639-45. doi: 10.1111/j.1365-2141.1977.tb00627.x.
The effects of testosterone and oestradiol on erythropoietin production by mouse fetal liver in primary culture was studied. No stimulatory effect on in vitro erythropoietin production was observed by any of the oestradiol concentrations employed [10(-10)M to 10(-6)M]: whereas testosterone, only over a dose range of 10(-12)M to 10(-10)M, stimulated erythropoietin production by mouse fetal liver in culture. In addition, a stimulatory effect of testosterone on fetal liver tissue was obtained by injecting testosterone (20 mg/mouse) intramuscularly into pregnant mice 4 d prior to obtaining the fetal liver tissue for culture. Therefore, it is concluded that testosterone can exert a direct stimulatory effect on erythropoietin production by mouse fetal liver.
研究了睾酮和雌二醇对原代培养的小鼠胎肝产生促红细胞生成素的影响。在所使用的任何雌二醇浓度（10⁻¹⁰M至10⁻⁶M）下，均未观察到对体外促红细胞生成素产生的刺激作用；而睾酮仅在10⁻¹²M至10⁻¹⁰M的剂量范围内，刺激培养的小鼠胎肝产生促红细胞生成素。此外，在获取用于培养的胎肝组织前4天，通过给怀孕小鼠肌肉注射睾酮（20mg/小鼠），获得了睾酮对胎肝组织的刺激作用。因此，得出结论：睾酮可对小鼠胎肝产生促红细胞生成素发挥直接刺激作用。
