Ussetti P, Urbina J, Pantoja C, Sidne J, Martínez J A, Martínez M A, Sánchez I, Cobos J, Rojas O
Hospital General del INSALUD, Guadalajara.
Enferm Infecc Microbiol Clin. 1996 Feb;14(2):80-5.
Tuberculin reactivity varies on the basis of the PPD lot and the population studied.
To compare tuberculin reactivity in the elderly following successive applications of PPD from 2 different lots.
Elderly nursing-home residents, from the province of Guadalajara, Spain.
The elderly were randomly selected and administered with a first Mantoux intradermoreaction of 2 UT of PPD-RT23 or 2 UT of PPD-CT68. The study was performed in a scaled basis, eliminating the reactors (transversal induration > or = 5 mm at 72 h). The non reactors were restudied with a second and third test in alternative arms at a 7-day interval with the same lot and initial dosis of PPD. At one year the scaled study was repeated with 2 UT of PPD-CT68.
Eight hundred and thirty elderly persons (79 +/- 9 years) were studied, with 410 receiving PPD-RT23 and 420 receiving PPD-CT68. No differences were observed in the percentage of initial reactors (31% vs 29%; p = 0.26) or in the booster reactors (23% vs 20%; p = 0.16). The PPD-RT23 was found to trigger more intensive reactions than the PPD-CT68 leading to a greater frequency of indurations > 14 mm. After one year, the percentage of stable reactions was similar in both groups (50.5% vs 49.5%; NS).
结核菌素反应性因结核菌素纯蛋白衍生物（PPD）批次和所研究人群的不同而有所差异。
比较连续应用来自2个不同批次的PPD后老年人的结核菌素反应性。
来自西班牙瓜达拉哈拉省的老年疗养院居民。
随机选择老年人，给予2单位结核菌素纯蛋白衍生物RT23（PPD-RT23）或2单位结核菌素纯蛋白衍生物CT68（PPD-CT68）进行首次结核菌素皮内试验。研究按比例进行，排除反应者（72小时时横向硬结≥5毫米）。对未出现反应者在7天间隔后用同一批次和初始剂量的PPD在交替组中进行第二次和第三次试验。一年后，用2单位PPD-CT68重复按比例进行的研究。
共研究了830名老年人（79±9岁），410人接受PPD-RT23，420人接受PPD-CT68。初始反应者的百分比（31%对29%；p = 0.26）或增强反应者的百分比（23%对20%；p = 0.16）均未观察到差异。发现PPD-RT23比PPD-CT68引发的反应更强烈，导致硬结>14毫米的频率更高。一年后，两组稳定反应的百分比相似（50.5%对49.5%；无显著性差异）。
1）在老年疗养院居民中，2单位PPD-RT23和2单位PPD-CT68在反应者数量和增强反应频率方面显示出相似结果。2）2单位PPD-RT23引发的强烈反应比例高于2单位PPD-CT68。3）一年时反应的稳定性与第一阶段使用的批次无关。
