Hachisuga T, Matsuo N, Iwasaka T, Sugimori H, Tsuneyoshi M
Department of Obstetrics and Gynecology, Fukuoka University, School of Medicine, Japan.
Pathology. 1996 Jan;28(1):28-31. doi: 10.1080/00313029600169463.
Inactivation of the wild type p53 protein through complexing of protein synthesized by specific subtypes of human papilloma virus (HPV) or mutation in the p53 gene in considered to play an important role in cervical carcinogenesis. The association between p53 overexpression and the presence of HPV 16 and 18 DNA was assessed in 29 cervical carcinomas, 15 carcinomas of the lower uterine segment and 30 endometrial carcinomas. In 29 cervical carcinomas (21 adenocarcinomas and 8 adenosquamous carcinomas), 7 cases were positive for HPV 16 DNA while 5 were positive for HPV 18 DNA. Nine cases (31%) showed p53 overexpression. An inverse association was seen between the presence of HPV DNA and the p53 overexpression. In 15 carcinomas of the lower uterine segment, one case was positive for HPV 16 DNA while 2 were positive for HPV 18 DNA. Overexpression of p53 was seen in 8 (53%) carcinomas of the lower uterine segment. Two of 3 HPV DNA positive carcinomas of the lower uterine segment revealed p53 overexpression. HPV DNA was not detected in endometrial carcinomas and p53 overexpression was shown in 12 (40%) cases. The association between HPV DNA and p53 overexpression differs among the tumors arising in the cervix, lower uterine segment and endometrium.
人乳头瘤病毒（HPV）特定亚型合成的蛋白质与野生型p53蛋白结合，或p53基因发生突变，从而使p53蛋白失活，这被认为在宫颈癌发生过程中起重要作用。对29例宫颈癌、15例子宫下段癌和30例子宫内膜癌进行了p53过表达与HPV 16和18 DNA存在情况的相关性评估。在29例宫颈癌（21例腺癌和8例腺鳞癌）中，7例HPV 16 DNA呈阳性，5例HPV 18 DNA呈阳性。9例（31%）显示p53过表达。HPV DNA的存在与p53过表达之间呈负相关。在15例子宫下段癌中，1例HPV 16 DNA呈阳性，2例HPV 18 DNA呈阳性。8例（53%）子宫下段癌出现p53过表达。子宫下段3例HPV DNA阳性癌中有2例显示p53过表达。子宫内膜癌未检测到HPV DNA，12例（40%）出现p53过表达。HPV DNA与p53过表达之间的相关性在宫颈、子宫下段和子宫内膜发生的肿瘤中有所不同。
