Bar J K, Markowska J, Harlozińska A, Sedlaczek P, Nowak M, Roszak A
Chair of Oncology, Faculty of Medicine, K. Marcinkowski University School of Medicine Poznań, Poland.
Eur J Gynaecol Oncol. 1996;17(4):283-5.
Infection with HPV type 16 was demonstrated in 54% of the cases and infection with HPV type 18 in 36.5% of the cases of uterine cervix carcinoma. Both types of viruses were present in 24.3% of the patients. P53 protein accumulation in cell nuclei was observed in 12.2% of the cases of uterine cervix carcinomas and the cases were mostly HPV negative while the cytoplasmic expression of p53 protein was present in 39% of the cases and was frequently accompanied by HPV infection. Presence of p21 protein was detected in 85.3% of the cases, independently of HPV infection or expression of p53 protein.
在54%的子宫颈癌病例中检测到16型人乳头瘤病毒（HPV）感染，36.5%的病例中检测到18型HPV感染。24.3%的患者同时存在这两种病毒。在12.2%的子宫颈癌病例中观察到细胞核中p53蛋白积累，这些病例大多为HPV阴性，而39%的病例中存在p53蛋白的细胞质表达，且常伴有HPV感染。85.3%的病例中检测到p21蛋白的存在，与HPV感染或p53蛋白表达无关。
