Laaroubi K, Vacherot F, Delbé J, Caruelle D, Barritault D, Courty J
Laboratoire de Recherche sur la Croissance Cellulaire, Université Paris Val de Marne, Créteil, France.
Prog Growth Factor Res. 1995;6(1):25-34. doi: 10.1016/0955-2235(95)00002-x.
Heparin affin regulatory peptide (HARP), also called Pleiotrophin (PTN), is a polypeptide that displays a high affinity for heparin and that shares approximately 50% sequence homology with Midkine (MK). According to this structural homology, these two molecules constitute a new family of heparin-binding proteins. The biological properties of HARP and MK remain largely a subject of debate. Both proteins have been described as neurite outgrowth promoting agents whereas until recently the mitogenic activity has been controversial. The aim of this review is to summarize the information on HARP with special focus on the recent data relating to its mitogenic properties.
肝素亲和调节肽（HARP），也称为多效生长因子（PTN），是一种对肝素有高亲和力的多肽，与中期因子（MK）具有约50%的序列同源性。根据这种结构同源性，这两种分子构成了一个新的肝素结合蛋白家族。HARP和MK的生物学特性在很大程度上仍是一个有争议的话题。这两种蛋白都被描述为神经突生长促进剂，而直到最近，其促有丝分裂活性一直存在争议。本综述的目的是总结关于HARP的信息，特别关注与其促有丝分裂特性相关的最新数据。
