聚（4-乙烯基吡啶-N-氧化物）对石棉纤维抑制病毒干扰素诱导的拮抗活性。
Antagonistic activity of poly (4-vinylpyridine-N-oxide) to the inhibition of viral interferon induction by asbestos fibres.
作者信息
Hahon N, Booth J A, Eckert H L
出版信息
Br J Ind Med. 1977 May;34(2):119-25. doi: 10.1136/oem.34.2.119.
The depressive activity of both serpentine (Canadian and Rhodesian chrysotiles) and amphibole (amosite, crocidolite, and anthophyllite) asbestos fibres on interferon induction by influenza virus was significantly diminished or abolished completely when either asbestos fibres or LLC-MK2 cell monolayers were pretreated with poly(4-vinylpyridine-N-oxide). Maximal antagonistic activity of the polymer was time and concentration dependent. Pretreating asbestos fibres with the polymer was more rapid and effective in encouraging viral interferon synthesis than pretreating cell monolayers. Virus multiplication in the presence of asbestos fibre-treated cell monolayers attained a twofold higher level than that noted in normal cell monolayers or those containing polymer-pretreated asbestos fibres. These findings were related to the suppression of interferon production.
当用聚（4-乙烯基吡啶-N-氧化物）预处理石棉纤维或LLC-MK2细胞单层时，蛇纹石（加拿大和罗德西亚温石棉）和闪石（铁石棉、青石棉和直闪石）石棉纤维对流感病毒诱导干扰素的抑制活性显著降低或完全消除。该聚合物的最大拮抗活性具有时间和浓度依赖性。用该聚合物预处理石棉纤维比预处理细胞单层在促进病毒干扰素合成方面更快且更有效。在存在经石棉纤维处理的细胞单层的情况下，病毒增殖水平比在正常细胞单层或含有经聚合物预处理的石棉纤维的细胞单层中高出两倍。这些发现与干扰素产生的抑制有关。
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