Plaza I, Díez-Tejedor E, Lara M, Barreiro P
Servicio de Neurología, Hospital Univ. La Paz, Universidad Autónoma, Madrid.
Rev Neurol. 1996 Feb;24(126):163-71.
Spontaneous dissection of the vertebral artery (VA) is an infrequent cause of vertebral-basilar ischaemia in children and young adults, being responsible for 4% of cases of ischaemic infarct in this age group. The distinction between spontaneous dissection and traumatic dissection helps to clarify its vascular tendency, not brought on by laceration of the vessel wall secondary to traumatism. It appears clinically with neck pain and/or headache, followed by a clinical picture of ischaemia in the vertebral-basilar area. Diagnosis is based on clinical suspicion and identification of the angiographic signs of dissection prognosis is favourable with good recuperation in 88% of cases and low recurrence risk. We present a series of seven patients with ischaemic stroke of the brainstem brought about by spontaneous VA dissection. We studied the patients using computerized tomography (CT) scan, magnetic resonance (MR) and brain angiography. The group comprised six men and one woman aged from 9 to 44 years. In one case localization was intracranial, in five there was earlier arterial pathology (hypoplasia or dysplasia) and in the remaining case dissection was bilateral. After a long-term follow-up of between one and seven years, not one of our patients showed any recurrence of ischaemic signs. We would suggest that spontaneous VA dissection should be considered in differential diagnosis in clinical pictures of vertebral-basilar ischaemia in children and young adults since most probably its frequency is greater than that currently supposed. The discussed data would support underlying arterial pathology as a tendency factor.
椎动脉自发性夹层是儿童和青年椎基底动脉缺血的罕见原因,占该年龄组缺血性梗死病例的4%。自发性夹层与创伤性夹层的区分有助于明确其血管倾向,并非由创伤继发的血管壁撕裂引起。临床上表现为颈部疼痛和/或头痛,随后出现椎基底动脉区域的缺血症状。诊断基于临床怀疑和夹层血管造影征象的识别。预后良好,88%的病例恢复良好,复发风险低。我们报告了一系列7例由椎动脉自发性夹层导致脑干缺血性卒中的患者。我们使用计算机断层扫描(CT)、磁共振成像(MR)和脑血管造影对患者进行了研究。该组包括6名男性和1名女性,年龄在9岁至44岁之间。1例病变位于颅内,5例存在早期动脉病变(发育不全或发育异常),其余1例夹层为双侧性。经过1至7年的长期随访,我们的患者均未出现缺血症状复发。我们建议,在儿童和青年椎基底动脉缺血的临床表现的鉴别诊断中应考虑椎动脉自发性夹层,因为其实际发生率很可能高于目前的推测。所讨论的数据支持潜在的动脉病变是一个倾向因素。