Mashiah M, Barishak Y R
Br J Ophthalmol. 1977 Jun;61(6):417-22. doi: 10.1136/bjo.61.6.417.
Fleurette is an expression of photoreceptor differentiation and its presence is said to indicate a good prognosis. Twenty-four eyes from 22 cases of retinoblastoma sent to the Mitrani Foundation laboratory between the years 1964 and 1976 were reviewed histologically and clinically. The presence of differentiation in the tumour was not always associated with a good prognosis. The most important prognostic factor seemed to be the length of time the tumour is allowed to remain in the eye. The longer it remains the more undifferentiated the tumour cells become and the greater the probability that it will spread into the choroid and the optic nerve and out of the eye through the sclera and metastasise throughout the body. The presence of gliosis seems to improve the prognosis.
菊形团是光感受器分化的一种表现，据说其存在预示着良好的预后。对1964年至1976年间送至米特拉尼基金会实验室的22例视网膜母细胞瘤患者的24只眼睛进行了组织学和临床检查。肿瘤中分化的存在并不总是与良好的预后相关。最重要的预后因素似乎是肿瘤在眼内停留的时间长度。停留时间越长，肿瘤细胞分化程度越低，扩散至脉络膜和视神经并通过巩膜穿出眼外并发生全身转移的可能性就越大。胶质增生的存在似乎能改善预后。
