Kaiya H, Iwata T, Moriuchi I, Namba M
Biol Psychiatry. 1977 Jun;12(3):323-30.
The population of synaptic vesicles per synaptic area in the hypothalamic ventromedial nucleus of rats treated with chlorpromazine (CP) for 3 days was compared with that of controls. In type I synapse, which contained 400-800 A small spherical vesicles (s-vesicles), together with 800-1200 A large spherical dense-cored vesicles (lc-vesicles), the population of s-vesicles increased 57.8% in the CP rats, In type II synapse, which contained only s-vesicles, the rate of increase among CP animals was 15.4%. Findings suggested that CP blocks the release of the vesicles from the presynaptic site or inhibits the transport function for biogenic amines through the presynaptic membrane, and type I synapse may be aminergic.
将用氯丙嗪（CP）处理3天的大鼠下丘脑腹内侧核中每个突触区域的突触小泡数量与对照组进行比较。在I型突触中，含有400 - 800埃的小球形囊泡（s - 囊泡）以及800 - 1200埃的大球形致密核心囊泡（lc - 囊泡），CP处理组大鼠的s - 囊泡数量增加了57.8%。在仅含有s - 囊泡的II型突触中，CP处理组动物的增加率为15.4%。研究结果表明，CP阻断了突触前部位囊泡的释放，或抑制了生物胺通过突触前膜的转运功能，并且I型突触可能是胺能的。
