Kaiya H, Iwata T, Ikeda K, Namba M
Experientia. 1978 May 15;34(5):645-9. doi: 10.1007/BF01937012.
The population of monoaminergic synaptic vesicles in the rat caudate nucleus remained unchanged or slightly decreased 3 h after chlorpromazine (CP) administration, and clearly increased after 24 h. The diameter of synaptic vesicles became smaller when the vesicles increased. These findings suggest that CP causes presynaptic blocking in part of its actions and leads to a condition in which neural transmission is inactive. In the control animals, population of the vesicles tended to fluctuate following the circadian rhythm.
给予大鼠氯丙嗪（CP）3小时后，其尾状核中含单胺能的突触小泡数量保持不变或略有减少，而在24小时后明显增加。当突触小泡数量增加时，其直径变小。这些发现表明，CP在其部分作用中导致突触前阻滞，并导致神经传递不活跃的状态。在对照动物中，突触小泡数量倾向于随昼夜节律波动。
