Effects of tamoxifen in relation to breast cancer.
作者信息
Jordan V C
出版信息
Br Med J. 1977 Jun 11;1(6075):1534-5. doi: 10.1136/bmj.1.6075.1534-d.
Abstract
摘要
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Effects of tamoxifen in relation to breast cancer.他莫昔芬与乳腺癌的关系及作用
Br Med J. 1977 Jun 11;1(6075):1534-5. doi: 10.1136/bmj.1.6075.1534-d.
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A new antiestrogen, 2-(4-hydroxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1H-indol-5-ol hydrochloride (ERA-923), inhibits the growth of tamoxifen-sensitive and -resistant tumors and is devoid of uterotropic effects in mice and rats.一种新型抗雌激素药物，2-(4-羟基苯基)-3-甲基-1-[4-(2-哌啶-1-基乙氧基)苄基]-1H-吲哚-5-醇盐酸盐（ERA-923），可抑制他莫昔芬敏感和耐药肿瘤的生长，且在小鼠和大鼠中无促子宫生长作用。
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Tamoxifen exerts agonistic effects on clusterin and complement C3 gene expression in RUCA-I primary xenografts and metastases but not normal uterus.他莫昔芬对RUCA-I原发性异种移植瘤和转移瘤中的簇集素和补体C3基因表达具有激动作用，但对正常子宫无此作用。
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本文引用的文献
1
Interactions of antiestrogens with human breast cancer in long-term tissue culture.抗雌激素与人类乳腺癌在长期组织培养中的相互作用。
Cancer Treat Rep. 1976 Oct;60(10):1421-9.
2
Antiestrogenic and antitumor properties of tamoxifen in laboratory animals.他莫昔芬在实验动物中的抗雌激素和抗肿瘤特性。
Cancer Treat Rep. 1976 Oct;60(10):1409-19.
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