Bringmann A
Department of Neurophysiology, University of Leipzig, Germany.
Naunyn Schmiedebergs Arch Pharmacol. 1996 Jan;353(2):168-74. doi: 10.1007/BF00168754.
The basal magnocellular nucleus is assumed to play a crucial role in cholinergic activation of the cortical EEG. The aim of this study was to establish whether intraperitoneally applied nicotine may counteract the power asymmetry of the slow waves in the cortical EEG of both hemispheres after an unilateral lesion in the basal nucleus. In 17 rats the basal nucleus (substantia innominata/ventral pallidum) was unilaterally lesioned by ibotenic acid. The lesion produced unilateral power increases of all frequencies up to 20 Hz in the frontal EEG that increased with higher arousal level. Additionally, synchronized spike and wave discharges appeared in the frontal EEG. The results indicate that the basal nucleus suppresses especially the delta EEG waves in the frontal motor cortex during motor active behaviour. Nicotine (0.1 and 1 mg/kg) partially counteracts the power asymmetry of frontal slow waves (2-6 Hz) only during exploratory sniffing but not during grooming and waking immobility. Physostigmine (1 mg/kg) was also effective during exploratory sniffing. The results may indicate a role of nicotinic mechanisms in the information input component of exploratory behaviour.
基底大细胞核被认为在皮质脑电图的胆碱能激活中起关键作用。本研究的目的是确定腹腔注射尼古丁是否可以抵消基底核单侧损伤后两侧半球皮质脑电图中慢波的功率不对称。在17只大鼠中，用鹅膏蕈氨酸单侧损伤基底核（无名质/腹侧苍白球）。损伤导致额叶脑电图中高达20Hz的所有频率的单侧功率增加，且随着觉醒水平的提高而增加。此外，额叶脑电图中出现同步的棘波和慢波放电。结果表明，在运动活跃行为期间，基底核尤其抑制额叶运动皮质中的δ脑电图波。尼古丁（0.1和1mg/kg）仅在探索性嗅探期间部分抵消额叶慢波（2-6Hz）的功率不对称，而在梳理和清醒不动期间则不能。毒扁豆碱（1mg/kg）在探索性嗅探期间也有效。结果可能表明烟碱机制在探索行为的信息输入成分中起作用。
