Bringmann A
Department of Neurophysiology, Paul Flechsig Institute for Brain Research, University of Leipzig, Germany.
Neuroreport. 1995 Oct 23;6(15):2065-8. doi: 10.1097/00001756-199510010-00026.
Previous investigations suggest a crucial role of the pedunculopontine tegmental nucleus (PPTg) in elicitation of cortical EEG alterations during paradoxical sleep. In order to reveal a participation of this nucleus in the regulation of the cortical EEG also during waking states and slow wave sleep unilateral ibotenic acid lesions of this nucleus were made in 12 Long-Evans rats. The lesion induced alterations of the frontal and occipital EEG were determined by FFT spectral power analysis. The lesion caused ipsilaterally a suppression of the hippocampal theta rhythm recorded on the occipital cortex during exploratory sniffing. During head washing the frontal delta waves were found to be elevated ipsilaterally. Suppressions of the slow sleep waves were found in the contralateral occipital as well as in the frontal EEG. The results indicate involvements of the PPTg in the regulation of the hippocampal and of the motor activity in waking states as well as in the regulation of the sleep delta waves.
先前的研究表明，脚桥被盖核（PPTg）在异相睡眠期间引发皮质脑电图改变中起关键作用。为了揭示该核在清醒状态和慢波睡眠期间对皮质脑电图调节的参与情况，对12只Long-Evans大鼠进行了该核的单侧鹅膏蕈氨酸损伤。通过快速傅里叶变换（FFT）频谱功率分析确定损伤引起的额叶和枕叶脑电图改变。损伤同侧导致在探索性嗅探期间枕叶皮质记录到的海马θ节律受到抑制。在洗头期间，发现同侧额叶δ波升高。在对侧枕叶以及额叶脑电图中发现慢睡眠波受到抑制。结果表明，脚桥被盖核参与清醒状态下海马和运动活动的调节以及睡眠δ波的调节。
