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[去氧肾上腺素给药对尿失禁及射精时尿道内口关闭动力学差异的实验评估]

[The experimental evaluation of the difference in closing dynamics of internal urethral ostium on the urinary continence and on the ejaculation induced by an administration of phenylephrine].

作者信息

Morita T, Nagamatsu H, Masuda H, Tosaka A, Nagahama K, Tsujii T, Kihara K, Ando M, Oshima H

机构信息

Department of Urology, Tokyo Medical and Dental University School of Medicine, Japan.

出版信息

Nihon Hinyokika Gakkai Zasshi. 1995 Dec;86(12):1761-9. doi: 10.5980/jpnjurol1989.86.1761.

Abstract

BACKGROUND

The internal urethral ostium is usually closed both on the ejaculation and on the urine collection, although the difference of the closing characteristics have not been known.

METHODS

The difference in closing style of bladder neck (internal urethral ostium) between on the phenylephrine administration corresponding state to the ejaculation and on the filling of urinary bladder corresponding state to the urinary continence was evaluated by Stereo-UPP method using mongrel dogs.

RESULTS

On phenylephrine administration, the length between verumontanum and bladder neck was lengthened, and a remarkable pressure increase was observed in the area. On the urinary continence filling physiological saline in the bladder, the length of the urethra on the UPP curve of the anterior wall of urethra was lengthened (10%) and the base of bladder was gradually become flat. The pressure in the bladder neck was not relatively increased.

CONCLUSIONS

The internal urethral ostium was closed both on the phenylephrine administration and on the urine collection, although the closing characteristics of each was very different. It was demonstrated that on the phenylephrine administration the area between the verumontanum and the bladder neck was lengthened, together with the rise of pressure in the area, whereas on the urine collection bladder neck was closed in low pressure by flattening the base of bladder.

摘要

背景

尿道内口在射精和尿液收集时通常都是关闭的,尽管其关闭特征的差异尚不清楚。

方法

使用杂种犬,通过立体尿道压力描记法(Stereo-UPP)评估在与射精相对应的去氧肾上腺素给药状态下和与尿失禁相对应的膀胱充盈状态下膀胱颈(尿道内口)关闭方式的差异。

结果

给予去氧肾上腺素时,精阜与膀胱颈之间的长度延长,且该区域观察到明显的压力升高。在膀胱内充盈生理盐水以实现尿失禁时,尿道前壁UPP曲线上的尿道长度延长(10%),膀胱底部逐渐变平。膀胱颈处的压力没有相对增加。

结论

尿道内口在给予去氧肾上腺素时和尿液收集时均是关闭的,尽管各自的关闭特征非常不同。结果表明,给予去氧肾上腺素时,精阜与膀胱颈之间的区域延长,同时该区域压力升高,而在尿液收集时,膀胱底部变平,膀胱颈在低压下关闭。

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