Moghadasian M H, Godin D V
Department of Pharmacology & Therapeutics, University of British Columbia, Canada.
Mol Cell Biochem. 1996 Feb 9;155(1):43-9. doi: 10.1007/BF00714332.
This study compared the activities of the antioxidant enzymes glutathione peroxidase, glutathione reductase and superoxide dismutase and the levels of glutathione in the mucosa of the body of the stomach, proximal and distal parts of the small intestine and the colon in male and female Sprague Dawley rats. Basal glutathione levels were significantly (p < 0.05) higher in the small intestine as compared with those in the other portions studied in both sexes. Except for colonic mucosa in females, the activity of glutathione reductase was similar in all the other tissues examined. Glutathione peroxidase showed the largest regional differences, with activities in the gastric segment being several-fold greater than those in small intestine or colon. This enzyme also showed marked gender-related differences, activity being greater in females than males in gastric mucosa and colon, while the converse was true for distal small intestine. In contrast, activities of superoxide dismutase showed minimal regional or gender-dependent variations.
本研究比较了雄性和雌性斯普拉格-道利大鼠胃体、小肠近端和远端以及结肠黏膜中抗氧化酶谷胱甘肽过氧化物酶、谷胱甘肽还原酶和超氧化物歧化酶的活性以及谷胱甘肽水平。两性的小肠中基础谷胱甘肽水平均显著高于（p < 0.05）所研究的其他部位。除雌性结肠黏膜外，所检查的所有其他组织中谷胱甘肽还原酶的活性相似。谷胱甘肽过氧化物酶的区域差异最大，胃段的活性比小肠或结肠中的活性高几倍。该酶还表现出明显的性别相关差异，胃黏膜和结肠中雌性的活性高于雄性，而远端小肠则相反。相比之下，超氧化物歧化酶的活性表现出最小的区域或性别依赖性变化。
