Vaughan-Jackson J D, Dunlop E M, Darougar S, Treharne J D, Taylor-Robinson D
Br J Vener Dis. 1977 Jun;53(3):180-3. doi: 10.1136/sti.53.3.180.
Ninety-five men suffering from gonococcal urethritis were treated and observed. Forty-nine developed postgonococcal non-specific urethritis (PGU). Seventeen men were demonstrated to be free from PGU after careful observation; these formed a control group. Chlamydia trachomatis was isolated from urethral material from 26 (53%) of the PGU group but from none of the controls. This difference was highly significant (P less than 0-001). It confirms that C. tachomatis is a pathogen in the urethra. The presence of specific IgM antibody to C. trachomatis in serum from some men developing PGU, from whom that organism was isolated, suggests that the infection was recent in those cases. Ureaplasma urealyticum (T strain mycoplasma) was isolated from urethral material taken from 22 (45%) of the 49 men in the PGU group, and from 12 (71%) of the 17 in the control group. Mycoplasma hominis was isolated from 10 (20%) of the 49 men in the PGU group, and from four (24%) of the 17 men in the control group. Thus, no evidence was obtained that mycoplasmas (U. urealyticum, M. hominis) are patogenic in the urethra.
对95例淋菌性尿道炎患者进行了治疗和观察。49例发生了淋菌后非特异性尿道炎（PGU）。经过仔细观察，有17名男性未出现PGU；这些人组成了一个对照组。从PGU组26例（53%）的尿道标本中分离出沙眼衣原体，但对照组中无一例分离出该病原体。这种差异具有高度显著性（P小于0.001）。这证实了沙眼衣原体是尿道中的一种病原体。在一些发生PGU且分离出该病原体的男性血清中存在针对沙眼衣原体的特异性IgM抗体，这表明在这些病例中感染是近期发生的。从PGU组49名男性中的22例（45%）以及对照组17名男性中的12例（71%）的尿道标本中分离出解脲脲原体（T株支原体）。从PGU组49名男性中的10例（20%）以及对照组17名男性中的4例（24%）的尿道标本中分离出人型支原体。因此，没有证据表明支原体（解脲脲原体、人型支原体）在尿道中具有致病性。
