活性肽的分子识别与信号转导的最新进展：阿片肽受体
Recent advances in molecular recognition and signal transduction of active peptides: receptors for opioid peptides.
作者信息
Kieffer B L
机构信息
Ecole Supérieure de Biotechnologie de Strabourg, Illkirch France.
出版信息
Cell Mol Neurobiol. 1995 Dec;15(6):615-35. doi: 10.1007/BF02071128.
Abstract
- Opioid peptides are a family of structurally related neuromodulators which play a major role in the control of nociceptive pathways. These peptides act through membrane receptors of the nervous system, defined as mu, delta and kappa and endowed with overlapping but distinct pharmacological, anatomical and functional properties. 2. Recent cloning of an opioid receptor gene family has opened the way to the use of recombinant DNA technology at the receptor level. 3. This review focuses on the molecular cloning and functional characterization of opioid receptors and provides first insights into molecular aspects of opioid peptide recognition and signal transduction mechanisms, using the cloned receptors as investigation tools.
摘要
- 阿片肽是一类结构相关的神经调质，在伤害性感受通路的调控中起主要作用。这些肽通过神经系统的膜受体发挥作用，这些受体被定义为μ、δ和κ受体，具有重叠但不同的药理学、解剖学和功能特性。2. 最近阿片受体基因家族的克隆为在受体水平使用重组DNA技术开辟了道路。3. 本综述聚焦于阿片受体的分子克隆和功能表征，并利用克隆的受体作为研究工具，对阿片肽识别和信号转导机制的分子层面提供了初步见解。
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本文引用的文献
1
cDNA cloning and pharmacological characterization of an opioid receptor with high affinities for kappa-subtype-selective ligands.对κ亚型选择性配体具有高亲和力的阿片受体的cDNA克隆及药理学特性研究
FEBS Lett. 1993 Sep 6;330(1):77-80. doi: 10.1016/0014-5793(93)80923-i.
2
Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes.大鼠阿片受体δ和μ亚型的初级结构及cDNA表达
FEBS Lett. 1993 Aug 2;327(3):311-4. doi: 10.1016/0014-5793(93)81011-n.
3
Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.小鼠脑内κ和δ阿片受体的克隆及功能比较
Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6736-40. doi: 10.1073/pnas.90.14.6736.
4
Molecular cloning and functional expression of a mu-opioid receptor from rat brain.大鼠脑μ-阿片受体的分子克隆与功能表达
Mol Pharmacol. 1993 Jul;44(1):8-12.
5
delta-Opioid receptor subtypes and cross-talk with mu-receptors.δ-阿片受体亚型及其与μ-受体的相互作用
Trends Pharmacol Sci. 1993 Mar;14(3):84-6. doi: 10.1016/0165-6147(93)90068-u.
6
Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel.大鼠G蛋白偶联毒蕈碱钾通道的一级结构与功能表达
Nature. 1993 Aug 26;364(6440):802-6. doi: 10.1038/364802a0.
7
Cloning and pharmacological characterization of a rat mu opioid receptor.大鼠μ阿片受体的克隆与药理学特性研究
Neuron. 1993 Nov;11(5):903-13. doi: 10.1016/0896-6273(93)90120-g.
8
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Biochem J. 1993 Nov 1;295 ( Pt 3)(Pt 3):629-33. doi: 10.1042/bj2950629.
9
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10
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