甘丙肽——一种具有抑制作用的神经肽。
Galanin--a neuropeptide with inhibitory actions.
作者信息
Kask K, Langel U, Bartfai T
机构信息
Department of Neurochemistry and Neurotoxicology, Stockholm University, Sweden.
出版信息
Cell Mol Neurobiol. 1995 Dec;15(6):653-73. doi: 10.1007/BF02071130.
Abstract
- Galanin is a 29 (in humans 30) amino acids long neuropeptide with mostly inhibitory, hyperpolarizing actions. 2. Differential structural requirements of truncated forms of galanin and differential agonist/antagonist behaviour of chimeric peptides, high affinity galanin receptor ligands suggest the presence of pharmacologically distinct galanin receptor subtypes. 3. The galanin receptor from human Bowes melanoma cell line--a member of G-protein coupled receptor superfamily--has been cloned. 4. Galanin acts via Gi/G(o) proteins inhibiting cAMP production, inositol phosphate turnover, opening K+ channels or closing Ca2+ channels.
摘要
- 甘丙肽是一种由29个（人类为30个）氨基酸组成的神经肽，主要具有抑制性、超极化作用。2. 甘丙肽截短形式的不同结构要求以及嵌合肽的不同激动剂/拮抗剂行为、高亲和力甘丙肽受体配体表明存在药理学上不同的甘丙肽受体亚型。3. 来自人鲍氏黑色素瘤细胞系的甘丙肽受体——G蛋白偶联受体超家族的一员——已被克隆。4. 甘丙肽通过Gi/G(o)蛋白发挥作用，抑制环磷酸腺苷（cAMP）生成、肌醇磷酸周转、开放钾离子通道或关闭钙离子通道。
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本文引用的文献
1
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Regul Pept. 1995 Nov 10;59(3):341-8. doi: 10.1016/0167-0115(95)00089-t.
2
Metabolism of galanin and galanin (1-16) in isolated cerebrospinal fluid and spinal cord membranes from rat.大鼠离体脑脊液和脊髓膜中甘丙肽及甘丙肽（1-16）的代谢
Neuropeptides. 1995 Sep;29(3):137-43. doi: 10.1016/0143-4179(95)90015-2.
3
Analogs of galanin (1-16) modified in positions 1-3 as ligands to rat hypothalamic galanin receptors.
Acta Chem Scand (Cph). 1994 May;48(5):434-8. doi: 10.3891/acta.chem.scand.48-0434.
4
Probing the brain and spinal cord with neuropeptides in pathways related to pain and other functions.
Front Neuroendocrinol. 1994 Sep;15(3):275-300. doi: 10.1006/frne.1994.1011.
5
Galanin receptors from human pituitary tumors assayed with human galanin as ligand.
Brain Res. 1993 Oct 15;625(1):173-6. doi: 10.1016/0006-8993(93)90152-d.
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