Zhang F, Van Bree L, Albala N, Verslype M, Vanderhaeghen J J
Brain Research Unit and Laboratory of Neuropathology and Neuropeptide Research, Université Libre de Bruxelles, Belgium.
Neurochem Int. 1996 Feb;28(2):189-92. doi: 10.1016/0197-0186(95)00070-4.
Using quantitative in situ hybridization, a significant decrease in expression of proenkephalin (27.1%) and of protachykinin mRNAs (20.0%) is observed in the rat caudate-putamen 14 days after daily intraperitoneal administration of N-methyl-D-aspartate receptor antagonist MK-801, 2 mg/kg.
运用定量原位杂交技术，发现在每日腹腔注射2毫克/千克的N-甲基-D-天冬氨酸受体拮抗剂MK-801 14天后，大鼠尾状核-壳核中的脑啡肽原表达显著下降（27.1%），速激肽原mRNA表达也显著下降（20.0%）。
