Angulo J A, Watanabe Y, Cadet J, Ledoux M, McEwen B S
Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021.
Eur J Pharmacol. 1993 Feb 15;244(3):317-8. doi: 10.1016/0922-4106(93)90158-6.
Blockade of NMDA (N-methyl-D-aspartate) receptors for 5 h with MK 801 resulted in elevated levels of proenkephalin mRNA (up to 40% above vehicle-injected controls) in medial and anterior aspects of the caudate-putamen (mCPU and aCPU) and the nucleus accumbens (NAc). Increases were dose-dependent, with maximal effect at 0.1 mg/kg (body weight). These results suggest that NMDA receptor activity exerts tonic inhibition on proenkephalin mRNA expression in the striatum and accumbens of the rat brain.
用MK 801阻断N-甲基-D-天冬氨酸（NMDA）受体5小时，导致尾壳核（mCPU和aCPU）和伏隔核（NAc）的内侧和前部脑啡肽原mRNA水平升高（比注射赋形剂的对照组高40%）。这种增加是剂量依赖性的，在0.1mg/kg（体重）时效果最大。这些结果表明，NMDA受体活性对大鼠脑纹状体和伏隔核中脑啡肽原mRNA的表达具有紧张性抑制作用。
