Vauthey J N, Dudrick P S, Lind D S, Copeland E M
Department of Surgery, University of Florida College of Medicine, Gainesville 32610-0286, USA.
Dig Dis. 1996 Jan-Feb;14(1):5-13. doi: 10.1159/000171535.
There is currently controversy regarding the use of serum carcinoembryonic antigen (CEA) in the follow-up of colorectal cancer. This article reviews the most recent clinical data regarding CEA and discusses the rationales for its use in the follow-up of colorectal cancer. The patterns of colorectal cancer recurrence and their variable association with CEA elevation are presented. The contributions of the new imaging modalities, including radiolabeled antibodies, are reviewed and information on the prognosis following resection of recurrences is provided. A practical approach to colorectal cancer recurrences is suggested in two algorithms.
目前，关于血清癌胚抗原（CEA）在结直肠癌随访中的应用存在争议。本文回顾了有关CEA的最新临床数据，并讨论了其在结直肠癌随访中应用的理论依据。介绍了结直肠癌复发模式及其与CEA升高的不同关联。综述了包括放射性标记抗体在内的新型成像模式的作用，并提供了复发切除术后的预后信息。通过两种算法提出了一种处理结直肠癌复发的实用方法。
