• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Endothelium-dependent relaxation to the B1 kinin receptor agonist des-Arg9-bradykinin in human coronary arteries.人冠状动脉对B1激肽受体激动剂去-精氨酸9-缓激肽的内皮依赖性舒张反应。
Br J Pharmacol. 1995 Dec;116(8):3083-5. doi: 10.1111/j.1476-5381.1995.tb15108.x.
2
Endothelium-dependent relaxations mediated by inducible B1 and constitutive B2 kinin receptors in the bovine isolated coronary artery.牛离体冠状动脉中由诱导型B1和组成型B2激肽受体介导的内皮依赖性舒张
Br J Pharmacol. 1995 Nov;116(5):2473-81. doi: 10.1111/j.1476-5381.1995.tb15098.x.
3
Haemodynamic and cardiac effects of kinin B1 and B2 receptor stimulation in conscious instrumented dogs.清醒插管犬中激肽B1和B2受体对血流动力学及心脏的影响
Br J Pharmacol. 1996 Apr;117(7):1565-71. doi: 10.1111/j.1476-5381.1996.tb15322.x.
4
Bradykinin B1 receptors in the rabbit urinary bladder: induction of responses, smooth muscle contraction, and phosphatidylinositol hydrolysis.兔膀胱中的缓激肽B1受体：反应诱导、平滑肌收缩及磷脂酰肌醇水解
Br J Pharmacol. 1995 Feb;114(3):612-7. doi: 10.1111/j.1476-5381.1995.tb17183.x.
5
Characterisation of bradykinin receptors from juvenile pig coronary artery.幼猪冠状动脉缓激肽受体的特性研究
Eur J Pharmacol. 1996 Feb 15;297(1-2):53-60. doi: 10.1016/0014-2999(95)00720-2.
6
The longitudinal muscle of rat ileum as a sensitive monoreceptor assay for bradykinin B1 receptors.大鼠回肠纵行肌作为缓激肽B1受体的敏感单受体检测方法。
Br J Pharmacol. 1996 Apr;117(8):1619-24. doi: 10.1111/j.1476-5381.1996.tb15331.x.
7
Bradykinin-induced vascular responses in dog isolated lingual artery.缓激肽对犬离体舌动脉的血管反应
Clin Exp Pharmacol Physiol. 1999 May-Jun;26(5-6):456-60. doi: 10.1046/j.1440-1681.1999.03057.x.
8
Different B1 kinin receptor expression and pharmacology in endothelial cells of different origins and species.不同来源和物种内皮细胞中B1激肽受体的表达及药理学特性各异。
J Pharmacol Exp Ther. 1997 Feb;280(2):1109-16.
9
The role of B1 and B2 kinin receptors in oedema formation after long-term treatment with Mycobacterium bovis bacillus Calmette-Guérin (BCG).B1和B2激肽受体在卡介苗（BCG）长期治疗后水肿形成中的作用。
Br J Pharmacol. 1997 Feb;120(3):502-8. doi: 10.1038/sj.bjp.0700914.
10
Interaction of bradykinin and des-Arg9-bradykinin with isolated pig coronary arteries: mechanical and electrophysiological events.缓激肽和去-精氨酸9-缓激肽与离体猪冠状动脉的相互作用：力学和电生理事件
Regul Pept. 1987 Apr;17(4):181-90. doi: 10.1016/0167-0115(87)90061-9.

引用本文的文献

1
Role of Endothelial Kinin B1 Receptor on the Membrane Potential of Transgenic Rat Aorta.内皮素 B1 受体在转基因大鼠主动脉膜电位中的作用。
Physiol Res. 2022 Aug 31;71(4):477-487. doi: 10.33549/physiolres.934904. Epub 2022 Jul 28.
2
gC1qR Antibody Can Modulate Endothelial Cell Permeability in Angioedema.gC1qR抗体可调节血管性水肿中内皮细胞的通透性。
Inflammation. 2022 Feb;45(1):116-128. doi: 10.1007/s10753-021-01532-w. Epub 2021 Sep 7.
3
ACE inhibition enhances bradykinin relaxations through nitric oxide and B1 receptor activation in bovine coronary arteries.血管紧张素转换酶抑制增强牛冠状动脉中通过一氧化氮和 B1 受体激活的缓激肽松弛作用。
Biol Chem. 2013 Sep;394(9):1205-12. doi: 10.1515/hsz-2012-0348.
4
Vasomotor and fibrinolytic responses to kinin receptor agonists in the atherosclerotic human lower limb.动脉粥样硬化的人类下肢对激肽受体激动剂的血管舒缩和纤溶反应。
Heart Vessels. 2012 Mar;27(2):179-85. doi: 10.1007/s00380-011-0124-6. Epub 2011 Mar 11.
5
Gene Variant of the Bradykinin B2 Receptor Influences Pulmonary Arterial Pressures in Heart Failure Patients.缓激肽B2受体基因变异影响心力衰竭患者的肺动脉压。
Clin Med Circ Respirat Pulm Med. 2009 Feb 17;2009(3):9-17.
6
Functional evidence of des-Arg10-kallidin enzymatic inactivating pathway in isolated human umbilical vein.人脐静脉中去-精氨酸10-缓激肽酶促失活途径的功能证据
Naunyn Schmiedebergs Arch Pharmacol. 2007 May;375(3):221-9. doi: 10.1007/s00210-007-0145-y. Epub 2007 Mar 20.
7
Endotoxin sensitization to kinin B(1) receptor agonist in a non-human primate model: haemodynamic and pro-inflammatory effects.非人灵长类动物模型中内毒素对缓激肽B(1)受体激动剂的致敏作用：血流动力学和促炎效应
Br J Pharmacol. 2001 Jan;132(1):327-35. doi: 10.1038/sj.bjp.0703748.
8
Inducible expression of the kinin B1 receptor in the endotoxemic heart: mechanisms of des-Arg9bradykinin-induced coronary vasodilation.内毒素血症心脏中缓激肽B1受体的诱导性表达：去精氨酸9缓激肽诱导冠状动脉舒张的机制
Br J Pharmacol. 1999 Sep;128(2):275-82. doi: 10.1038/sj.bjp.0702743.
9
Protease-activated receptor-2 turnover stimulated independently of receptor activation in porcine coronary endothelial cells.蛋白酶激活受体-2的周转在猪冠状动脉内皮细胞中独立于受体激活而受到刺激。
Br J Pharmacol. 1999 Jun;127(3):617-22. doi: 10.1038/sj.bjp.0702583.
10
Kinin receptors.激肽受体
Clin Rev Allergy Immunol. 1998 Winter;16(4):385-401. doi: 10.1007/BF02737658.

本文引用的文献

1
Induction of bradykinin B1 receptor-mediated relaxation in the isolated rabbit carotid artery.缓激肽B1受体介导的离体兔颈动脉舒张作用的诱导
Eur J Pharmacol. 1993 Aug 3;239(1-3):63-7. doi: 10.1016/0014-2999(93)90976-o.
2
[Cardiac dysfunction and endogenous cytokines in global ischemia and reperfusion injury].[全心缺血再灌注损伤中的心脏功能障碍与内源性细胞因子]
Hokkaido Igaku Zasshi. 1993 Nov;68(6):813-26.
3
Pharmacological reactivity of human epicardial coronary arteries: characterization of relaxation responses to endothelium-derived relaxing factor.人类心外膜冠状动脉的药理反应性：对内皮源性舒张因子舒张反应的特征描述
Br J Pharmacol. 1994 Dec;113(4):1099-104. doi: 10.1111/j.1476-5381.1994.tb17109.x.
4
Pharmacological reactivity of human epicardial coronary arteries: phasic and tonic responses to vasoconstrictor agents differentiated by nifedipine.人类心外膜冠状动脉的药理反应性：硝苯地平区分的对血管收缩剂的时相性和紧张性反应
Br J Pharmacol. 1994 Dec;113(4):1093-8. doi: 10.1111/j.1476-5381.1994.tb17108.x.
5
Changes in bradykinin level in coronary sinus blood after the experimental occlusion of a coronary artery.冠状动脉实验性闭塞后冠状窦血中缓激肽水平的变化。
Am Heart J. 1973 May;85(5):635-47. doi: 10.1016/0002-8703(73)90169-5.
6
Characterization and function of bradykinin receptors in vascular endothelial cells.血管内皮细胞中缓激肽受体的表征与功能
J Pharmacol Exp Ther. 1988 Oct;247(1):8-13.
7
Relaxation of isolated mesenteric arteries by des-Arg9-bradykinin stimulation of B1 receptors.通过刺激B1受体，des-Arg9-缓激肽使离体肠系膜动脉舒张。
Eur J Pharmacol. 1986 Oct 14;130(1-2):11-8. doi: 10.1016/0014-2999(86)90178-0.

人冠状动脉对B1激肽受体激动剂去-精氨酸9-缓激肽的内皮依赖性舒张反应。

Endothelium-dependent relaxation to the B1 kinin receptor agonist des-Arg9-bradykinin in human coronary arteries.

作者信息

Drummond G R, Cocks T M

机构信息

Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia.

出版信息

Br J Pharmacol. 1995 Dec;116(8):3083-5. doi: 10.1111/j.1476-5381.1995.tb15108.x.

DOI:10.1111/j.1476-5381.1995.tb15108.x
PMID:8719780
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1909186/
Abstract

Des-Arg9-bradykinin (des-Arg9-BK) caused endothelium-dependent relaxations in human, isolated coronary arteries which upregulated with in vitro incubation time. Relaxations to des-Arg9-BK were inhibited by the B1 receptor antagonist, des-Arg9-[Leu3]-BK (pK(B), 6.14 +/- 0.11) but were unaffected by the B2 receptor antagonist, Hoe-140. Therefore, this is the first demonstration that human coronary arteries possess endothelial B1 receptors which mediate endothelium-dependent relaxation and appear to be synthesized de novo during the incubation period.

摘要

去-精氨酸9-缓激肽（des-Arg9-BK）可引起人离体冠状动脉的内皮依赖性舒张，且这种舒张作用会随着体外孵育时间的延长而增强。去-精氨酸9-BK引起的舒张作用被B1受体拮抗剂去-精氨酸9-[亮氨酸3]-缓激肽（pK(B)，6.14±0.11）抑制，但不受B2受体拮抗剂Hoe-140的影响。因此，这是首次证明人冠状动脉拥有内皮B1受体，该受体介导内皮依赖性舒张，并且在孵育期间似乎是重新合成的。