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亚洲一个发展中国家与惊厥性疾病相关的死亡率:20年趋势

Mortality related to convulsive disorders in a developing country in Asia: trends over 20 years.

作者信息

Senanayake N, Peiris H

机构信息

Department of Medicine, Faculty of Medicine, University of Peradeniya, Sri Lanka.

出版信息

Seizure. 1995 Dec;4(4):273-7. doi: 10.1016/s1059-1311(95)80004-2.

Abstract

The cause of death as recorded in 37125 death certificates (DC) issued in the Kandy District over 20 years at five-year intervals beginning 1967 was analysed to determine the trends in mortality caused by convulsive disorders in the community. Convulsions accounted for 881 (23.7/1000) deaths, the highest number being in infancy (35.8%). A slight male preponderance of 51.5% was observed. Most of the deaths occurred in the periphery (51.6%) and in the tea estates (36.3%) as opposed to town area (12.0%). "Febrile convulsions' was the most common diagnosis in 396 (44.9%) deaths. "Convulsions' which included neonatal and infantile convulsions accounted for 186 (21.1%) deaths. Other causes included chest complications (60, 6.8%), drowning (28, 3.2%), asphyxia (20, 2.3%), status epilepticus (19, 2.2%), burns (7, 0.8%), and poisoning (2, 0.2%). The proportion of deaths due to convulsive disorders showed a decrease from 37.28/1000 in 1967 to 9.55/1000 in 1987, which was most evident in the periphery, from 60.49/1000 to 13.19/1000. This parallelled a drop in the proportion of deaths attributed to "febrile convulsions' and "convulsions'. The study shows the need to educate the public about first-aid and the subsequent management of convulsions, especially in childhood. Health personnel in developing countries should consider it mandatory to make a specific diagnosis in children who present as febrile convulsions. Appropriate antiepileptic medication and compliance can prevent death due to status epilepticus and injuries associated with seizures.

摘要

分析了1967年开始的20年间在康提地区每隔五年签发的37125份死亡证明(DC)中记录的死因,以确定社区中惊厥性疾病导致的死亡率趋势。惊厥导致881人死亡(23.7/1000),其中婴儿期死亡人数最多(35.8%)。观察到男性略占优势,为51.5%。大多数死亡发生在周边地区(51.6%)和茶园(36.3%),而城镇地区为(12.0%)。“热性惊厥”是396例(44.9%)死亡中最常见的诊断。包括新生儿和婴儿惊厥在内的“惊厥”导致186例(21.1%)死亡。其他原因包括胸部并发症(60例,6.8%)、溺水(28例,3.2%)、窒息(20例,2.3%)、癫痫持续状态(19例,2.2%)、烧伤(7例,0.8%)和中毒(2例,0.2%)。惊厥性疾病导致的死亡比例从1967年的37.28/1000下降到1987年的9.55/1000,在周边地区最为明显,从60.49/1000降至13.19/1000。这与“热性惊厥”和“惊厥”导致的死亡比例下降相平行。该研究表明需要对公众进行急救以及惊厥后续处理的教育,尤其是在儿童期。发展中国家的卫生人员应将对表现为热性惊厥的儿童进行明确诊断视为强制性要求。适当的抗癫痫药物治疗和依从性可以预防癫痫持续状态导致的死亡以及与癫痫发作相关的损伤。

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