吗啡增强肝胆闪烁显像：一项荟萃分析。
Morphine-augmented hepatobiliary scintigraphy: a meta-analysis.
作者信息
Cabana M D, Alavi A, Berlin J A, Shea J A, Kim C K, Williams S V
机构信息
Johns Hopkins University Hospital, Baltimore, MD, USA.
出版信息
Nucl Med Commun. 1995 Dec;16(12):1068-71. doi: 10.1097/00006231-199512000-00013.
The aim of this study was to compare the sensitivity and specificity of morphine-augmented hepatobiliary scintigraphy (MA-HBS) with that of conventional hepatobiliary scintigraphy (C-HBS) for acute cholecystitis. The results of most MA-HBS studies cannot be compared with C-HBS estimates, since articles describing C-HBS often include non-candidates for MA-HBS. However, using meta-analytic techniques to combine data from eligible studies (4 for C-HBS and 5 for MA-HBS), the specificity of MA-HBS (0.84; 95% CI = 0.75-0.94) was significantly greater (P = 0.008) than that of C-HBS (0.68; 95% CI = 0.61-0.75); there were no differences in sensitivity (MA-HBS; 0.96, 95% CI = 0.92-0.99; C-HBS: 0.97, 95% CI = 0.97-0.99).
本研究的目的是比较吗啡增强肝胆闪烁显像（MA-HBS）与传统肝胆闪烁显像（C-HBS）对急性胆囊炎诊断的敏感性和特异性。大多数MA-HBS研究的结果无法与C-HBS的评估结果进行比较，因为描述C-HBS的文章往往纳入了不适合MA-HBS的患者。然而，采用荟萃分析技术合并符合条件的研究数据（C-HBS有4项研究，MA-HBS有5项研究），MA-HBS的特异性（0.84；95%可信区间=0.75-0.94）显著高于C-HBS（0.68；95%可信区间=0.61-0.75）（P = 0.008）；敏感性方面无差异（MA-HBS为0.96，95%可信区间=0.92-0.99；C-HBS为0.97，95%可信区间=0.97-0.99）。
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