Nenoff P, Horn L C, Mierzwa M, Leonhardt R, Weidenbach H, Lehmann I, Haustein U F
Department of Dermatology, University of Leipzig, Germany.
Mycoses. 1995 Nov-Dec;38(11-12):467-71. doi: 10.1111/j.1439-0507.1995.tb00021.x.
Immunocompromised and granulocytopenic patients and those receiving long-term or high-dose corticoid treatment are predisposed to disseminating Aspergillus infections. However, Aspergillus infection has been described only rarely in patients with autoimmune diseases. We report on a woman suffering from systemic lupus erythematosus treated by antibiotics and high-dose corticosteroids, a primary risk factor, who developed a peracute disseminated fatal Aspergillus fumigatus infection involving the central nervous system. The present case is compared with 10 previous reports of invasive aspergillosis in systemic lupus erythematosus found by a literature search.
免疫功能低下和粒细胞减少的患者以及接受长期或大剂量皮质类固醇治疗的患者易发生播散性曲霉菌感染。然而，自身免疫性疾病患者中曲霉菌感染的报道极为罕见。我们报告了一名患有系统性红斑狼疮的女性，她接受了抗生素和大剂量皮质类固醇治疗（这是一个主要危险因素），随后发生了累及中枢神经系统的超急性播散性致命烟曲霉菌感染。通过文献检索，将本病例与之前10例系统性红斑狼疮侵袭性曲霉病的报告进行了比较。
