Gustafson T L, Schaffner W, Lavely G B, Stratton C W, Johnson H K, Hutcheson R H
J Infect Dis. 1983 Aug;148(2):230-8. doi: 10.1093/infdis/148.2.230.
During a 31-month period in 1979-1981, nine patients at a renal transplant center in Tennessee developed invasive infections with Aspergillus species. Despite an extensive search, no common environmental source of contamination was found. A matched case-control study of host risk factors showed that leukopenia, prior administration of antibiotics, and treatment with azathioprine and antilymphocyte serum were not significantly related to the development of aspergillosis. In contrast, the administration of high-dose corticosteroids posed a significant risk. An average daily dose of greater than or equal to 1.25 mg of prednisone/kg per day for the entire interval studied was the best predictor of subsequent invasive infection with Aspergillus.
在1979年至1981年的31个月期间，田纳西州一家肾移植中心的9名患者发生了曲霉菌属的侵袭性感染。尽管进行了广泛的调查，但未发现常见的环境污染源。一项关于宿主危险因素的配对病例对照研究表明，白细胞减少、先前使用抗生素以及硫唑嘌呤和抗淋巴细胞血清治疗与曲霉菌病的发生没有显著相关性。相比之下，大剂量使用皮质类固醇构成了重大风险。在整个研究期间，平均每日剂量大于或等于1.25毫克泼尼松/千克/天是随后发生曲霉菌侵袭性感染的最佳预测指标。
