Horsten S F, van den Berg A J, Kettenes-van den Bosch J J, Leeflang B R, Labadie R P
Department of Pharmacognosy, Universiteit Utrecht, Netherlands.
Planta Med. 1996 Feb;62(1):46-50. doi: 10.1055/s-2006-957795.
From the latex of Jatropha gossypifolia L. (Euphorbiaceae) a novel cyclic heptapeptide was isolated, which we named cyclogossine A. A combination of amino acid analysis, FAB mass spectrometry, and two dimensional 1H-NMR spectroscopy (TOCSY and ROESY) was used to determine the primary structure. The compound was found to contain one glycine, one alanine, one valine, two leucine, one threonine, and one tryptophan residue; its amino acid sequence is: Leu 1 - Ala 2 - Thr 3 - Trp 4 - Leu 5 - Gly 6 - Val 7. The absolute configurations of the amino acids were determined by chiral gas chromatography; all have the L-configuration.
从麻疯树（大戟科）的乳胶中分离出一种新型环七肽，我们将其命名为环麻疯树碱A。采用氨基酸分析、快原子轰击质谱和二维¹H-NMR光谱（TOCSY和ROESY）相结合的方法来确定其一级结构。发现该化合物含有一个甘氨酸、一个丙氨酸、一个缬氨酸、两个亮氨酸、一个苏氨酸和一个色氨酸残基；其氨基酸序列为：Leu 1 - Ala 2 - Thr 3 - Trp 4 - Leu 5 - Gly 6 - Val 7。通过手性气相色谱法确定了氨基酸的绝对构型；均为L-构型。
