van den Berg A J, Horsten S F, Kettenes-van den Bosch J J, Kroes B H, Beukelman C J, Leeflang B R, Labadie R P
Department of Pharmacognosy, Faculty of Pharmacy, Universiteit Utrecht, The Netherlands.
FEBS Lett. 1995 Jan 30;358(3):215-8. doi: 10.1016/0014-5793(94)01405-p.
From the latex of Jatropha curcas L. (Euphorbiaceae) a novel cyclic octapeptide was isolated, which we named curcacycline A. The compound was found to contain one threonine, one valine, two glycine, and four leucine residues. By two-dimensional 1H-NMR spectroscopy (HOHAHA and ROESY), its sequence was determined to be Gly1-Leu2-Leu3-Gly4-Thr5-Val6-Leu7-Leu8-Gly1+ ++. Curcacycline A displays a moderate inhibition of (i) classical pathway activity of human complement and (ii) proliferation of human T-cells.
