Ljunggren H G, Thorpe C J
Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden.
Histol Histopathol. 1996 Jan;11(1):267-74.
Class I molecules of the major histocompatibility complex (MHC) are expressed on the cell surface of almost all nucleated mammalian cells. Their main function is to transport and present peptides, derived from intracellularly degraded proteins, to cytotoxic T cells (CTL). They are also directly involved in the process leading to maturation and selection of a functional CD8+ T cell repertoire. MHC class I molecules consist of a highly polymorphic membrane spanning heavy chain of approximately 45 kD that is non-covalently associated with a light chain, beta 2-microglobulin (beta 2m). Class I molecules bind peptides, usually 8-11 amino acids in length. The majority of the class I-bound peptides are generated in the cytosol and are subsequently translocated into the lumen of the endoplasmic reticulum (ER) through the ATP-dependent transporter associated with antigen processing 1/2 (TAP1/2). Here, we provide an up-to-date review summarizing the most essential parts relating to MHC class I-mediated antigen processing, presentation and T cell selection. A particular emphasis is devoted to the structure of MHC class I molecule, and MHC class I-bound peptides.
主要组织相容性复合体（MHC）的I类分子在几乎所有有核哺乳动物细胞的表面表达。它们的主要功能是将细胞内降解蛋白衍生的肽转运并呈递给细胞毒性T细胞（CTL）。它们还直接参与导致功能性CD8 + T细胞库成熟和选择的过程。MHC I类分子由一条高度多态性的跨膜重链组成，重链约45kD，与轻链β2-微球蛋白（β2m）非共价结合。I类分子结合通常长度为8-11个氨基酸的肽。大多数与I类结合的肽在胞质溶胶中产生，随后通过与抗原加工相关的ATP依赖性转运体1/2（TAP1/2）转运到内质网（ER）腔中。在这里，我们提供了一篇最新综述，总结了与MHC I类介导的抗原加工、呈递和T细胞选择相关的最重要部分。特别强调了MHC I类分子的结构以及与MHC I类结合的肽。
