Flutter Barry, Gao Bin
Infection and Immunity, Institute of Child Health, University College London, UK.
Cell Mol Immunol. 2004 Feb;1(1):22-30.
Presentation of antigenic peptide to T cells by major histocompatibility complex (MHC) class I molecules is the key to the cellular immune response. Non-self intracellular proteins are processed into short peptides and transported into endoplasmic reticulum (ER) where they are assembled with class I molecules assisted by several chaperone proteins to form trimeric complex. MHC class I complex loaded with optimised peptides travels to the cell surface of antigen presentation cells to be recognised by T cells. The cells presenting non-self peptides are cleared by CD8 positive T cells. In order to ensure that T cells detect an infection or mutation within the target cells the process of peptide loading and class I expression must be carefully regulated. Many of the cellular components involved in antigen processing and class I presentation are known and their various functions are now becoming clearer.
主要组织相容性复合体（MHC）I类分子将抗原肽呈递给T细胞是细胞免疫反应的关键。非自身细胞内蛋白质被加工成短肽并转运到内质网（ER）中，在那里它们在几种伴侣蛋白的协助下与I类分子组装形成三聚体复合物。装载有优化肽的MHC I类复合物迁移到抗原呈递细胞的细胞表面，以供T细胞识别。呈递非自身肽的细胞会被CD8阳性T细胞清除。为了确保T细胞检测到靶细胞内的感染或突变，肽加载和I类表达过程必须受到严格调控。许多参与抗原加工和I类呈递的细胞成分已为人所知，它们的各种功能现在也越来越清晰。
