Mietz H, Arnold G, Kirchhof B, Krieglstein G K
Department of Ophthalmology, University of Cologne, Germany.
Graefes Arch Clin Exp Ophthalmol. 1996 Feb;234(2):131-6. doi: 10.1007/BF00695253.
Pyogenic granulomas are ulcerated vascular proliferations, often accompanied by inflammatory infiltrates, which rarely affect the eye. Only few reports on pyogenic granulomas of the cornea have been presented.
The enucleated globe containing the corneal tumor was examined histopathologically, and special immunohistochemical stains were performed.
The lesion had a yellowish appearance with marked vascularization. The inflammatory infiltrate was mainly composed of mononuclear cells, with no multinucleated giant cells, and was located anterior to Bowman's layer, leaving the corneal stroma unaffected. Immunohistochemical studies outlined the high vascular content, even in dense cellular areas, and confirmed the inflammatory nature of the mononuclear infiltrates.
Pyogenic granuloma of the cornea represents a clinical and morphological entity developing in a traumatized eye with corneal vascularization. Although the origin of these lesions remains obscure, there have been no signs of malignancy. Therefore, enucleation of an eye with a pyogenic granuloma should be avoided.
化脓性肉芽肿是溃疡性血管增生，常伴有炎症浸润，很少累及眼部。关于角膜化脓性肉芽肿的报道较少。
对含有角膜肿瘤的摘除眼球进行组织病理学检查，并进行特殊免疫组织化学染色。
病变呈淡黄色外观，血管明显增生。炎症浸润主要由单核细胞组成，无多核巨细胞，位于Bowman层前方，角膜基质未受影响。免疫组织化学研究显示即使在密集细胞区域血管含量也很高，并证实了单核浸润的炎症性质。
角膜化脓性肉芽肿是一种在有角膜血管化的受伤眼中发生的临床和形态学实体。尽管这些病变的起源仍不清楚，但尚无恶性迹象。因此，应避免对患有化脓性肉芽肿的眼睛进行摘除。
