van Everdingen-Bongers J J, Janssen P, Lammens M, Stricker B H, Bravenboer B
Afd. Inwendige Ziekten, Catharina Ziekenhuis, Eindhoven.
Ned Tijdschr Geneeskd. 1996 Feb 10;140(6):320-2.
After her holiday in South Africa, a 50-year-old woman was admitted because of fever and pain in the upper abdomen. The laboratory tests showed moderately increased serum liver enzyme activities. The liver biopsy showed a granulomatous hepatitis. Further investigations revealed no evidence for sarcoidosis, tuberculosis or infectious hepatitis, nor for other granulomatous diseases or infectious diseases relevant to South Africa. Upon discontinuation of the malaria prophylaxis with Daraclor (pyrimethamine and chloroquine (sulphate)) the symptoms disappeared and the liver function tests returned to normal. It was concluded that Daraclor was the probable cause of granulomatous hepatitis in this patient. This adverse effect was not published before.
一名50岁女性在南非度假后，因发热和上腹部疼痛入院。实验室检查显示血清肝酶活性中度升高。肝脏活检显示为肉芽肿性肝炎。进一步检查未发现结节病、结核病或传染性肝炎的证据，也未发现与南非相关的其他肉芽肿性疾病或传染病的证据。停用抗疟疾药物达拉氯（乙胺嘧啶和氯喹（硫酸盐））后，症状消失，肝功能检查恢复正常。结论是达拉氯可能是该患者肉芽肿性肝炎的病因。这种不良反应以前未曾报道过。
