Abe Masanori, Kumagi Teru, Nakanishi Seiji, Yamagami Takashi, Michitaka Kojiro, Abe Kayo, Okura Izumi, Yamashita Haruhiko, Horiike Norio, Onji Morikazu
Third Department of Internal Medicine, Ehime University School of Medicine, Shigenobu-cho, Ehime 791-0295, Japan.
J Gastroenterol. 2002;37(12):1068-72. doi: 10.1007/s005350200180.
A 38-year-old Japanese woman with no past history of liver disease developed liver dysfunction associated with fever, anorexia, and general malaise following the prolonged administration of saridon. A liver biopsy demonstrated multiple noncaseating epithelioid granulomas within hepatic lobules, with an inflammatory cell infiltrate of the lobular parenchyma and portal tracts. Viral markers and autoantibodies were negative. Lymphocyte stimulation tests for saridon and for isopropylantipyrine, one of the constituents of saridon, were positive, and therefore a diagnosis of drug-induced hepatitis due to administration of saridon was made. Her symptoms resolved and liver function test results returned to normal following discontinuation of the drug. The possibility of drug-induced hepatitis must be considered when liver dysfunction or systemic symptomatology develops during saridon therapy.
一名38岁无肝脏疾病既往史的日本女性，在长期服用索米痛片后出现了与发热、厌食和全身不适相关的肝功能障碍。肝脏活检显示肝小叶内有多个非干酪样上皮样肉芽肿，小叶实质和汇管区有炎性细胞浸润。病毒标志物和自身抗体均为阴性。索米痛片及其成分之一异丙安替比林的淋巴细胞刺激试验呈阳性，因此诊断为服用索米痛片所致的药物性肝炎。停药后她的症状消失，肝功能检查结果恢复正常。在索米痛片治疗期间出现肝功能障碍或全身症状时，必须考虑药物性肝炎的可能性。
