Stadler H P, Strasser M, Meier P, Tontis A, Hofmann M, Ruggli N, Peterbans E
Institut für Veterinär-Virologie, Universität Bern.
Schweiz Arch Tierheilkd. 1996;138(2):63-6.
As indicated by their nucleotide sequences bovine viral diarrhea viruses (BVD-virus) are genetically quite heterogenous. Despite differences in the nucleotide sequence in the NS3 region, we found that the derived amino acid sequence of all viral strains analyzed was identical and differed from that of classical swine fever viruses, thus allowing differentiation between bovine and porcine pestiviruses. Remarkably, the BVD viral strains were isolated over a time period of some 40 years in Europe, North America and New Zealand. The nucleotide sequence of the 5' untranslated genome region of a BVD virus recently isolated in Switzerland from a calf with hemorrhagic syndrome differs from that of BVD viruses causing similar symptoms in a large epidemic outbreak in North America.
正如其核苷酸序列所示，牛病毒性腹泻病毒（BVD病毒）在基因上具有相当大的异质性。尽管NS3区域的核苷酸序列存在差异，但我们发现，所有分析的病毒株推导的氨基酸序列是相同的，且与经典猪瘟病毒的氨基酸序列不同，从而能够区分牛瘟病毒和猪瘟病毒。值得注意的是，这些BVD病毒株是在欧洲、北美和新西兰约40年的时间里分离得到的。最近在瑞士从一头患有出血综合征的小牛身上分离出的一种BVD病毒的5'非翻译基因组区域的核苷酸序列，与在北美一次大规模疫情爆发中引起类似症状的BVD病毒的核苷酸序列不同。
