Annunziato L, Di Renzo G F, Schettini G, Scapagnini U, Preziosi P
Cancer Res. 1977 Aug;37(8 Pt 1):2574-7.
A single i.p. injection of vincristine (1000 microgram/kg) into rats increased the plasma concentration of corticosterone after a latent period of 4 hr; the effect lasted for 48 hr. The response was dose related with the threshold dose being 100 microgram/kg and the maximal effect occurring after 250 microgram/kg. Vincristine also increased plasma corticosterone levels in hypophysectomized rats, suggesting that the drug may have a direct action on the adrenal gland. The injection of 500 or 1000 microgram/kg also reduced the plasma concentration of thyroid-stimulating hormone. Twelve and 18 hr after the injection of vincristine (1000 microgram/kg), the plasma concentration of thyroid-stimulating hormone was reduced, whereas the hypothalamic content of norepinephrine, a neurotransmitter involved in the regulation of thyrotropin-releasing hormone-thyroid-stimulating hormone secretion, remained unchanged. The adrenocortical stimulation produced by vincristine may play some role in the antineoplastic effects of this drug.
给大鼠腹腔注射一次长春新碱（1000微克/千克）后，经过4小时的潜伏期，皮质酮的血浆浓度升高；这种作用持续48小时。该反应与剂量相关，阈剂量为100微克/千克，250微克/千克后出现最大效应。长春新碱还可提高垂体切除大鼠的血浆皮质酮水平，提示该药可能对肾上腺有直接作用。注射500或1000微克/千克还会降低促甲状腺激素的血浆浓度。注射长春新碱（1000微克/千克）后12小时和18小时，促甲状腺激素的血浆浓度降低，而参与促甲状腺激素释放激素-促甲状腺激素分泌调节的神经递质去甲肾上腺素的下丘脑含量保持不变。长春新碱产生的肾上腺皮质刺激可能在该药的抗肿瘤作用中发挥一定作用。
