Grota L J
Dev Psychobiol. 1981 May;14(3):221-8. doi: 10.1002/dev.420140311.
The plasma corticosterone response to various doses of serotonin and 5-hydroxytryptophan was studied in the 3-day-old rat. The maximum response to both drugs occurred 60 min after injection. Increased corticosterone concentration was observed at lower doses of serotonin than of 5-hydroxytryptophan. The effects of serotonin injection on Days 1-7 after birth on the plasma corticosterone response to 3 min of novelty stimulation at weaning was also studied. Serotonin treatment resulted in reduced adrenocortical reactivity which was reduced further when fluoxetine was given prior to the serotonin. Shocking rat pups on Days 1-7 also reduced adrenocortical reactivity and fluoxetine prior to shock further reduced adrenocortical reactivity when administered twice per day.
研究了3日龄大鼠对不同剂量血清素和5-羟色氨酸的血浆皮质酮反应。两种药物的最大反应均在注射后60分钟出现。血清素剂量低于5-羟色氨酸时，皮质酮浓度就出现升高。还研究了出生后第1至7天注射血清素对断奶时3分钟新奇刺激引起的血浆皮质酮反应的影响。血清素处理导致肾上腺皮质反应性降低，在血清素给药前给予氟西汀时，肾上腺皮质反应性进一步降低。出生后第1至7天电击幼鼠也会降低肾上腺皮质反应性，电击前每天两次给予氟西汀会进一步降低肾上腺皮质反应性。
