Torre E A, Fulco R A
Istituto Nazionale per la Ricerca sul Cancro, Genova.
Minerva Ginecol. 1995 Dec;47(12):553-6.
pS2 is a small protein (7000 daltons) that is prevalently expressed in human breast cancer positive for estrogen receptors: protein is, in fact, induced by estrogen stimulation. Studies indicate that pS2 protein is a marker for hormone-dependent breast tumors and that its expression is helpful in the prognosis. The presence of pS2, in fact, besides being associated in 96% of the cases to the positivities for estrogen receptors, is associated with longer overall, and disease free, survival. The pS2 protein is also expressed in normal stomach mucosa; its physiological function is unknown.
pS2是一种小蛋白（7000道尔顿），在雌激素受体阳性的人类乳腺癌中普遍表达：事实上，该蛋白是由雌激素刺激诱导产生的。研究表明，pS2蛋白是激素依赖性乳腺肿瘤的一个标志物，其表达有助于预后判断。实际上，pS2的存在除了在96%的病例中与雌激素受体阳性相关外，还与更长的总生存期和无病生存期相关。pS2蛋白也在正常胃黏膜中表达；其生理功能尚不清楚。
