Rio M C, Chambon P
Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France.
Cancer Cells. 1990 Aug-Sep;2(8-9):269-74.
Approximately 50% of human breast tumors secrete a small cysteine-rich protein called pS2. In the human breast cancer cell line MCF-7, expression of the pS2 protein is strongly induced by estrogen, and cloning and sequence analysis of the pS2 gene has revealed an "estrogen responsive element" in the gene's 5'-flanking region. The results of immunohistochemical assays and radioimmunoassays on breast cancer biopsies indicate that the pS2 protein is a marker for hormone-dependent breast tumors and that its expression is associated with longer overall, and disease-free, survival. The pS2 protein is also expressed in normal stomach mucosa and in regenerative tissues in ulcerative diseases of the gastrointestinal tract. Its physiological function is unknown.
大约50%的人类乳腺肿瘤会分泌一种名为pS2的富含半胱氨酸的小蛋白。在人类乳腺癌细胞系MCF-7中，雌激素可强烈诱导pS2蛋白的表达，对pS2基因的克隆和序列分析显示，该基因的5'侧翼区域存在一个“雌激素反应元件”。对乳腺癌活检组织进行免疫组织化学检测和放射免疫分析的结果表明，pS2蛋白是激素依赖性乳腺肿瘤的标志物，其表达与更长的总生存期和无病生存期相关。pS2蛋白也在正常胃黏膜以及胃肠道溃疡性疾病的再生组织中表达。其生理功能尚不清楚。
