Urakami T, Sugamura K, Niki E
Biochemicals Division, Mitsubishi Gas Chemical Co., Tokyo, Japan.
Biofactors. 1995;5(2):75-81.
Imidazopyrroloquinoline (IPQ) compounds synthesized from coenzyme PQQ (pyrroloquinoline quinone) and various kinds of amino acids were characterized. IPQ was synthesized from coenzyme PQQ and one of three amino acids (glycine, L-tryptophan and L-tyrosine). Two kinds of IPQ compound were formed from coenzyme PQQ and L-serine. At higher pH, IPQ was synthesized, at lower pH hydroxy-methyl-IPQ was synthesized. IPQ with R of amino acids represented by R-CH(NH2)-COOH was synthesized from coenzyme PQQ and other amino acids. IPQ compounds do not act as cofactor of glucose dehydrogenase. Molar absorption coefficients of IPQ are 31,400 M-1 cm-1 at 251 nm, 30,700 M-1 cm-1 at 276 nm, and 20,700 M-1 cm-1 at 423 nm at pH 7.0 and room temperature.
对由辅酶PQQ（吡咯并喹啉醌）与各种氨基酸合成的咪唑并吡咯喹啉（IPQ）化合物进行了表征。IPQ由辅酶PQQ与三种氨基酸（甘氨酸、L-色氨酸和L-酪氨酸）之一合成。由辅酶PQQ和L-丝氨酸形成了两种IPQ化合物。在较高pH值下合成IPQ，在较低pH值下合成羟甲基-IPQ。由辅酶PQQ和其他氨基酸合成了氨基酸R以R-CH(NH2)-COOH表示的IPQ。IPQ化合物不作为葡萄糖脱氢酶的辅因子。在pH 7.0和室温下，IPQ在251 nm处的摩尔吸收系数为31400 M-1 cm-1，在276 nm处为30700 M-1 cm-1，在423 nm处为20700 M-1 cm-1。
