Fujii K, Kawata M, Kobayashi Y, Okamoto A, Nishinari K
Research Center, Denki Kagaku Kogyo Co., Ltd., Tokyo, Japan.
Biopolymers. 1996 May;38(5):583-91. doi: 10.1002/(SICI)1097-0282(199605)38:5%3C583::AID-BIP4%3E3.0.CO;2-O.
The effects of the addition of sodium hyaluronate segments (sHA) with different chain lengths on the viscoelasticity of high molecular weight sodium hyaluronate (HA) aqueous solutions were studied. The additive effects of sHA depended on the chain length of sHA. Shorter sHA decreased storage (G') and loss (G") moduli, whereas longer sHA increased both moduli. In physiological saline, the effects of the addition of sHA depended on the chain length of sHA, as in aqueous solutions, except that shorter segments did not decrease both moduli. The effects of the addition of monosaccharides, i.e., N-acetyl glucosamine (GlcNAc) and sodium glucuronate (GlcANa), were also studied. Although GlcNAc increased G' and G", GlcANa decreased both moduli. A shift factor "A," which depended on chain-length effects, a sugar effect, and a salt effect, was developed to explain these additive effects quantitatively.
研究了添加不同链长的透明质酸钠片段（sHA）对高分子量透明质酸钠（HA）水溶液粘弹性的影响。sHA的添加效果取决于sHA的链长。较短的sHA降低了储能模量（G'）和损耗模量（G''），而较长的sHA则增加了这两种模量。在生理盐水中，添加sHA的效果与在水溶液中一样，取决于sHA的链长，只是较短的片段不会同时降低这两种模量。还研究了添加单糖，即N-乙酰葡糖胺（GlcNAc）和葡糖醛酸钠（GlcANa）的效果。虽然GlcNAc增加了G'和G''，但GlcANa降低了这两种模量。开发了一个取决于链长效应、糖效应和盐效应的位移因子“A”，以定量解释这些添加效果。
