Lee W Y, Lee J M, Park K H, Park C, Chang M, Hong W P, Park I Y
Department of Microbiology, Yonsei University, College of Medicine, Seoul, South Korea.
Acta Virol. 1995 Dec;39(5-6):269-74.
Coxiella burnetii is a well-known causative agent of granulomatous inflammation and an inducer of morphological changes and transformation of human B lymphocytes in vitro. An association of the organism with polymorphic reticulosis (PMR), a malignant granulomatous inflammation characterized by polymorphic lymphocytes, was examined. The infection of C. burnetii was demonstrated in all cases tested, especially in polymorphic lymphocytes. Also the presence of morphologically transformed peripheral blood lymphocytes (PBLs) infected with C. burnetii was demonstrated. In cultures of blood lymphocytes, C. burnetii-infected polymorphic cells identified as B cells became immortalized in vitro. These findings implicate the role of C. burnetii in the process of PMR.
伯纳特立克次氏体是肉芽肿性炎症的著名病原体，也是体外人类B淋巴细胞形态变化和转化的诱导剂。研究了该生物体与多形性网状细胞增多症（PMR）的关联，PMR是一种以多形性淋巴细胞为特征的恶性肉芽肿性炎症。在所有测试病例中均证实存在伯纳特立克次氏体感染，尤其是在多形性淋巴细胞中。还证实了感染伯纳特立克次氏体的形态转化外周血淋巴细胞（PBL）的存在。在血液淋巴细胞培养物中，被鉴定为B细胞的感染伯纳特立克次氏体的多形性细胞在体外永生化。这些发现暗示了伯纳特立克次氏体在PMR过程中的作用。
