Day R S, Dimattina M
Chem Biol Interact. 1977 Apr;17(1):89-97. doi: 10.1016/0009-2797(77)90074-6.
Chlorpromazine, a substituted phenothiazine, commonly used as a sedative, has been found to photosensitize the inactivation of human adenovirus 5 to wavelengths of light between 330 and 390 nm. The slope of the inactivation curve is three fold greater when fibroblasts from people having xeroderma pigmentosum (XP) were used as viral hosts than when normal fibroblasts were used, showing that at least two-thirds of the damage produced in the virions is repairable by normal human fibroblasts. The phototreatment of chlorpromazine sensitized virions also results in the production of DNA strand breaks, which correlate fairly well with the production of lethal viral damage as measured in XP fibroblasts. These findings suggest that the photosensitization of the skin observed in patients treated with chlorpromazine might be due to DNA damage.
氯丙嗪是一种取代吩噻嗪，常用作镇静剂，已发现它能使人类腺病毒5在330至390纳米波长的光线下发生光致敏失活。当使用患有色素性干皮病（XP）的人的成纤维细胞作为病毒宿主时，失活曲线的斜率比使用正常成纤维细胞时大三倍，这表明病毒颗粒中至少三分之二的损伤可被正常人成纤维细胞修复。氯丙嗪致敏病毒颗粒的光处理还会导致DNA链断裂，这与在XP成纤维细胞中测量的致死性病毒损伤的产生相当吻合。这些发现表明，用氯丙嗪治疗的患者中观察到的皮肤光致敏可能是由于DNA损伤。
