Graham S J, Bronskill M J
Department of Medical Biophysics, University of Toronto, Ontario, Canada.
Magn Reson Med. 1996 May;35(5):706-15. doi: 10.1002/mrm.1910350512.
MR techniques providing accurate measurement of relative volumetric water content and multicomponent T2 relaxation times from a large volume of interest, have been implemented for characterization of breast tissue in vivo. In a sequence of 20-s breath-holds, data are obtained from much of the breast volume while suppressing signal from the chest wall and torso. Relative water content of each breast is calculated from one-dimensional fat and water profiles obtained using a hybrid two-point Dixon method (TE/TR = 17/5000 ms). Multicomponent T2 relaxation measurements are calculated from T2 decay curves obtained using a CPMG train of rectangular pulses (TE/TR = 8/5000 ms, 140 echoes) preceded by saturation pulses to localize longitudinal magnetization spatially. These techniques, validated in phantoms and human volunteers, are suitable for quantitative study of breast tissue in vivo, and in particular to investigate the potential role of MR for assessment of breast cancer risk.
能够从大感兴趣体积中准确测量相对体积含水量和多组分T2弛豫时间的磁共振技术，已被用于体内乳腺组织的表征。在一系列20秒屏气过程中，在抑制胸壁和躯干信号的同时，从大部分乳腺体积中获取数据。每个乳房的相对含水量由使用混合两点狄克逊方法（TE/TR = 17/5000 ms）获得的一维脂肪和水分布计算得出。多组分T2弛豫测量值由使用矩形脉冲CPMG序列（TE/TR = 8/5000 ms，140个回波）并在之前加饱和脉冲以在空间上定位纵向磁化强度而获得的T2衰减曲线计算得出。这些技术在体模和人类志愿者中得到验证，适用于体内乳腺组织的定量研究，特别是用于研究磁共振在评估乳腺癌风险方面的潜在作用。
