White M H
Infectious Disease Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Clin Infect Dis. 1996 May;22 Suppl 2:S124-7. doi: 10.1093/clinids/22.supplement_2.s124.
Early in the AIDS epidemic, retrospective studies reported that vaginal candidiasis occurred more frequently in women who were infected with human immunodeficiency virus (HIV) than in those who were not infected. Some investigators suggested that new onset or recurrent vaginal candidiasis might identify HIV-infected individuals and predict the course of AIDS in women already known to be infected. In this article, studies of vaginal candidiasis in HIV-infected women are examined, and several observations are made. First, early studies were small and likely reflected biased populations. Second, adherence to previously accepted diagnostic criteria for vaginal candidiasis was not consistent in these studies. Finally, conclusions about the increased risk of recurrent or chronic candidal vaginitis in HIV-infected women have been promulgated in the medical literature and may have influenced clinical practice even though such statements are not supported epidemiologically. Prospective trials with uninfected community controls should determine the true impact of HIV infection on vulvovaginal candidiasis.
在艾滋病流行早期，回顾性研究报告称，感染人类免疫缺陷病毒（HIV）的女性比未感染的女性更容易发生阴道念珠菌病。一些研究人员认为，新发或复发性阴道念珠菌病可能有助于识别HIV感染者，并预测已知感染的女性艾滋病病程。在本文中，对HIV感染女性的阴道念珠菌病研究进行了审视，并得出了几点观察结果。首先，早期研究规模较小，可能反映的是有偏差的人群。其次，这些研究中对先前公认的阴道念珠菌病诊断标准的遵循并不一致。最后，尽管这些说法在流行病学上没有依据，但关于HIV感染女性复发性或慢性念珠菌性阴道炎风险增加的结论已在医学文献中公布，可能已经影响了临床实践。采用未感染的社区对照进行的前瞻性试验应该能够确定HIV感染对外阴阴道念珠菌病的真正影响。
